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Since soluble urate, xanthine oxidase inhibitor treatment, and free fatty acids modulate inflammation, our findings suggest that by suppressing lipolysis, ULT could regulate inflammation in gout and comorbid metabolic and cardiovascular disease

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328,329 Similarly, IGF-I induces senescence of HSCs, inactivates these cells, and limits fibrosis in a p53-dependent manner

Discussion In this study, we evaluated the protective effects and mechanism of action of caffeine and EGCG treatments against HFHC diet-induced NASH in mice